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Side effects of finasteride usage

In order for a medicine to be approved by the FDA it needs to go through several testing phases. At first any possible toxicity needs to be eliminated. The next step is to test increasing dosages on healthy human subjects to make sure it's safe to continue testing. The following step is to check whether there is any efficacy for the presumed illness. If this is the case, the final step will be testing the drug on patients in order to assess efficacy, effectiveness, and safety.

Finasteride research in the final step of clinical testing under 1879 men has shown that it promotes hair growth and prevents further hair loss in a significant amount of men that suffer from common baldness. Furthermore, the hair growth that was gained over the first year is maintained after the second year. Photographs of men who encountered hair loss on the vertex have shown that 48 per cent of them showed improvement in hair growth after the first year and 66 per cent after the second year. The therapeutic dosage was well tolerated, with 7.7 per cent of men receiving 1mg finasteride on a daily base reporting side effects versus 7.0 per cent of the patients who received a placebo. The total reported sexual side effects of this group was significantly larger in men who received finasteride compared to those who received a placebo, with 3.8 per cent and 2.1 per cent respectively. These sexual side effects consisted of function disorders related to the male's ejaculation, libido, and erection. All sexual side effects disappeared after discontinuation of the finasteride administration whereas the men who continued the therapy kept experiencing these side effects.

Other side effects that have shown to be related to finasteride are anxiety and depression. A study was conducted under 128 men with male pattern baldness who were administered a daily dose of 1mg finasteride. The aim of the study was to examine if a finasteride dosage that conforms with the FDA approved hair loss treatment of 1mg per day, might cause mood swings such as anxiety and depression. The mood levels were measured before and after the experiment using questionnaires. The results showed that there was a noticeable (significant) increase in depressive symptoms. The researchers responsible for this study recommend that men with a higher risk for depression should be carefully screened before finasteride is subscribed to them.

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